CAMPYLOBACTER JEJUNI LIPOPOLYSACCHARIDES FROM GUILLAIN-BARRE SYNDROME PATIENTS INDUCE IGG ANTI-GM1 ANTIBODIES IN RABBITS
Lipopolysaccharides (LPS) from Campylobacter jejuni strains isolated from patients with Guillain-Barre syndrome (GBS) display molecular mimicry with GM1. We immunized rabbits with C. jejuni LPS from GBS-associated strains containing a GM1-like epitope. All animals produced high titre anti-LPS antibodies that were cross-reactive with GM1. We conclude that C. jejuni strains from GBS patients are able to induce antibodies that cross-react with gangliosides and LPS. This study further confirms the role of molecular mimicry in the induction of anti-ganglioside antibodies in GBS patients.
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Document Type: Abstract
Affiliations: Journal of Neuroimmunology 104: 133–138, 2000. Reprinted with permission from Elsevier Science BV.
Publication date: December 1, 2000