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Rapid and Simple GC–MS Method for Determination of Psychotropic Phenylalkylamine Derivatives in Nails Using Micro‐Pulverized Extraction*

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Abstract:  A rapid and simple gas chromatography–mass spectrometry (GC–MS) method was developed and validated for the simultaneous detection and quantification of five psychotropic phenylalkylamines (amphetamine, methamphetamine, 3,4‐methylenedioxyamphetamine, 3,4‐methylenedioxymethamphetamine, and norketamine) in toenails. After external decontamination, nail clippings were mechanically pulverized with a bead mill and then incubated in methanol under ultrasonication at 50°C for 1 h. The resulting solutions were evaporated to dryness, derivatized, and analyzed by GC–MS. The intra‐ and inter‐day precisions were within 10.7% and 13.9%, respectively. The intra‐ and inter‐day accuracies were −4.2% to 5.0% and −2.4% to 8.4%, respectively. Limits of detection and quantification for each analyte were lower than 0.024 and 0.08 ng/mg, respectively. The recoveries were in the range of 80.6–87.5%. The results indicated that the proposed method is a simple, rapid, accurate, and precise for quantification of five phenylalkylamines in nails. The method was successfully applied to the simultaneous detection and quantification of phenylalkylamines in nail samples of possible drug abusers.
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Document Type: Research Article

Affiliations: Drug Analysis Laboratory, Forensic Science Division, Supreme Prosecutors’ Office, 706 Banporo, Seochogu, Seoul 137-730, Korea.

Publication date: January 1, 2012

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