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A Y-chromosome STR Marker Should Be Added to Commercial Multiplex STR Kits

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Abstract: 

Autosomal short tandem repeat (STR) analysis has become highly relevant in the identification of victims from mass disasters and terrorist attacks. In such events, gender misidentification can be of grave consequences, yet the list reporting amelogenin amplification failure using STR multiplex kits continues to grow. Presented here are three such examples. In the first case, we present two male suspects who demonstrated amelogenin Y-deficient results using two commercial kit procedures. The presence of their Y chromosomes was proven by obtaining a Y-haplotype. The second case demonstrated a profile from a third male suspect where only the Y homolog of the XY pair was amplified. In events such as mass disasters or terrorist attacks, timely and reliable high throughput DNA typing results are essential. As the number of reported cases of amplification failure at the amelogenin gene continues to grow, we suggest that the incorporation of a better gender identification tool in commercial kits is crucial.
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Keywords: STR multiplex kits; X chromosome; Y chromosome; Y marker; amelogenin; forensic science; gender typing; mutation

Document Type: Research Article

Affiliations: 1: DNA Database Laboratory, Division of Identification and Forensic Science (DIFS), Israel Police, National H.Q., Jerusalem, Israel. 2: Forensic Biology Laboratory, Division of Identification and Forensic Science (DIFS), Israel Police, National H.Q., Jerusalem, Israel.

Publication date: July 1, 2008

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