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Open Access Garlic (Allium sativum) as an anti-Candida agent: a comparison of the efficacy of fresh garlic and freeze-dried extracts

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k.m. lemar, m.p. turner and d. lloyd. 2002.

Aims: To determine the effects of fresh and freeze-dried extracts of Allium sativum on the physiology and morphology of Candida albicans.

Methods and Results: Inhibition of growth in glucose-yeast extract-peptone was measured using a multiwell plate reader. Scanning and transmission electron microscopy investigations indicated loss of structural integrity. Gas chromatography-mass spectrometry of extracts was employed to separate and quantify putative inhibitory sulphur-containing components.

Conclusions: Fresh garlic extract has a greater efficacy than garlic powder extract as indicated both by its effects on morphology and inhibition of growth.

Significance and Impact of the Study: The ubiquitous opportunistic pathogen C. albicans is sensitive to garlic; resistance to the broad spectrum of active principles present is unlikely so that its anticandidal effects may provide an important alternative route to chemotherapy.
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Document Type: Research Article

Affiliations: Microbiology (BIOSI 1), Cardiff University, Cardiff, Wales, UK

Publication date: September 1, 2002

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