Preparation and Characterization of Porous Bioglass® and
PLLA Scaffolds for Tissue Engineering Applications
Three‐dimensional porous scaffold network structures of Bioglass® and poly‐
l‐lactide ( PLLA) have been fabricated using camphene‐based freeze cast reticulation technique using polyurethane foam templates
of appropriate structures and solvent extraction methods. Sublimation of camphene was controlled during freeze casting of Bioglass® slurries at −78°C. PLLA scaffolds were prepared by solvent extraction at temperatures between 25°C and −196°C.
Both methods produced open, uniform and interconnected porous structures with 180–1100 μm and porosities of 80%–90% for Bioglass® and wide pore size ranges 150–600 μm with porosities up to 90% for PLLA scaffolds. PLLA
scaffolds exhibited a strong dependence on freezing temperature and type of the solvent used. Camphene sublimation resulted in micropores of 1–10 μm, known to facilitate cell adhesion and proliferation. Compressive yield strength of 0.8 MPa close to the upper range of cancellous
bone was achieved. The mean compressive strength of Bioglass® scaffolds compared favorably with the theoretical model of porosity variation with strength and was higher than reported values. A maximum of 25% shrinkage resulted, but the original foam template structure was accurately
replicated within 4% experimental limit and the conformity was maintained even at high temperatures. The strut sizes of both type of scaffolds varied between 4‐10 μm. Surface crystallization up to 5 μm was evident at 900°C.
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Document Type: Research Article
Publication date: September 1, 2012