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In Situ Bone-Like Apatite Formation From a Bioeutectic® Ceramic in SBF Dynamic Flow

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In a previous study, a new ceramic material (Bioeutectic®), prepared by slow solidification through the eutectic temperature-composition region of the wollastonite–tricalcium phosphate system, was found to be bioactive in static-simulated body fluid. The eutectic material reacts by dissolving the pseudowollastonite phase and forming a hydroxyapatite-like porous structure by a pseudomorphic transformation of the tricalcium phosphate lamellae, which in turn mimics porous bone. Later, a hydroxyapatite-like layer is formed by precipitation on the surface of the material. In the present study, the bioactivity of the Bioeutectic® material was assessed in dynamic simulated body fluid in order to improve the ingrowth of new bone into implants (osteointegration). Samples of the material were soaked for 2 weeks in a dynamic simulated body fluid (1 mL/min) at 37°C. The experiment showed that there is no precipitation of hydroxyapatite-like layer on the surface of a the material. Otherwise, a complete transformation of the eutectic material takes place, giving rise to a hydroxyapatite artificial porous bone. The dynamic model used in this study may be better than the usual static immersion model in imitating the physiological condition of bone-like apatite formation.
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Document Type: Research Article

Affiliations: 1: Instituto de Cerámica y Vidrio, CSIC. C/Kelsen 5, 28049 Madrid, Spain 2: Instituto de Bioingeniería, Universidad Miguel Hernández, 03202 Elche, Alicante, Spain 3: Departamento de Ciencia y Tecnología de Materiales, Universidad Miguel Hernández, 03202 Elche, Alicante, Spain

Publication date: April 1, 2007

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