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Biocompatibility of Fluor-Hydroxyapatite Bioceramics

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Fluoridated hydroxyapatite (FHA) powders were fabricated by a solid-state reaction, and their dense bodies were obtained by sintering at 1350°C. The biological performance of FHAs was evaluated and compared with that of pure hydroxyapatite (HA). The fluoridation of FHAs was confirmed by the changes in their lattice parameters. Human osteoblast-like cells attached and proliferated well on all of the FHAs, including pure FA. The proliferation and differentiation levels of the cells on FHAs were similar to those on pure HA. This finding suggests that the FHAs possess cell viability and activity comparable to pure HA, and thus are potentially applicable as hard tissue substitutes.
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Document Type: Research Article

Affiliations: School of Materials Science and Engineering, Seoul National University, Seoul 151-742, Korea

Publication date: May 1, 2005

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