Skip to main content
padlock icon - secure page this page is secure

Free Content The atypical IκB protein IκBNS is important for Toll‐like receptor‐induced interleukin‐10 production in B cells

Download Article:
Although a major function of B cells is to mediate humoral immunity by producing antigen‐specific antibodies, a specific subset of B cells is important for immune suppression, which is mainly mediated by the secretion of the anti‐inflammatory cytokine interleukin‐10 (IL‐10). However, the mechanism by which IL‐10 is induced in B cells has not been fully elucidated. Here, we report that IκBNS, an inducible nuclear IκB protein, is important for Toll‐like receptor (TLR)‐mediated IL‐10 production in B cells. Studies using IκBNS knockout mice revealed that the number of IL‐10‐producing B cells is reduced in IκBNS −/− spleens and that the TLR‐mediated induction of cytoplasmic IL‐10‐positive cells and IL‐10 secretion in B cells are impaired in the absence of IκBNS. The impairment of IL‐10 production by a lack of IκBNS was not observed in TLR‐triggered macrophages or T‐cell‐receptor‐stimulated CD4+ CD25+ T cells. In addition, IκBNS‐deficient B cells showed reduced expression of Prdm1 and Irf4 and failed to generate IL‐10+ CD138+ plasmablasts. These results suggest that IκBNS is selectively required for IL‐10 production in B cells responding to TLR signals, so defining an additional role for IκBNS in the control of the B‐cell‐mediated immune responses.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: IκBNS; Toll‐like receptors; interleukin‐10‐producing B cells

Document Type: Research Article

Publication date: April 1, 2016

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more