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Medically refractory neurosarcoidosis treated with infliximab

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Abstract

Neurosarcoidosis can worsen despite standard immunosuppressive therapy, a situation for which there is no established medical management. We present three cases of medically refractory neurosarcoidosis treated with infliximab. All three patients showed a clinical response to this treatment and side effects were limited. A summary of reported cases of neurosarcoidosis treated with infliximab is included. This case series supports a role for infliximab in the treatment of patients with medically refractory neurosarcoidosis.
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Keywords: anti-inflammatory agent; factor-alpha; infliximab; monoclonal antibody; sarcoidosis; tumour necrosis

Document Type: Research Article

Affiliations: 1: Department of Neurology, Auckland City Hospital, Auckland 2: Department of Neurology, Christchurch Hospital, Christchurch, New Zealand

Publication date: April 1, 2011

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