Transmission of triple-class, drug-resistant HIV-1 in Australia
We report the first two cases of transmitted triple-class, drug-resistant HIV-1 in Australia. Baseline testing of a newly diagnosed man showed four reverse transcriptase resistance mutations (affecting two drug classes) and six protease resistance mutations. A source patient was identified, and a likely second case newly infected 1 year later, suggesting sequential transmission. This raises therapeutic implications for the individual patients, as well as public health concerns.
Document Type: Research Article
Affiliations: 1: HIV, Immunology and Infectious Diseases Unit, St Vincent's Hospital 2: School of Biotechnology and Biomolecular Sciences, University of New South Wales 3: Immunovirology and Pathogenesis Program, National Centre in HIV Epidemiology & Clinical Research, HIV, Immunology and Infectious Diseases Unit, St Vincent's Hospital, Sydney, New South Wales, Australia
Publication date: September 1, 2010