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Transmission of triple-class, drug-resistant HIV-1 in Australia

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We report the first two cases of transmitted triple-class, drug-resistant HIV-1 in Australia. Baseline testing of a newly diagnosed man showed four reverse transcriptase resistance mutations (affecting two drug classes) and six protease resistance mutations. A source patient was identified, and a likely second case newly infected 1 year later, suggesting sequential transmission. This raises therapeutic implications for the individual patients, as well as public health concerns.
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Keywords: HIV; HIV-1; antiretroviral agent; disease transmission; drug resistance; infectious; multiple; viral

Document Type: Research Article

Affiliations: 1: HIV, Immunology and Infectious Diseases Unit, St Vincent's Hospital 2: School of Biotechnology and Biomolecular Sciences, University of New South Wales 3: Immunovirology and Pathogenesis Program, National Centre in HIV Epidemiology & Clinical Research, HIV, Immunology and Infectious Diseases Unit, St Vincent's Hospital, Sydney, New South Wales, Australia

Publication date: September 1, 2010

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