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‘Free’ surfactant in gastric aspirates and bronchoalveolar lavage in children with and without reflux oesophagitis

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Aim: Dipalmitoylphosphatidycholine (DPPC) is the characteristic and main constituent of surfactant. Adsorption of surfactant to epithelial surfaces may be important in the masking of receptors. The aims of the study were to (i) compare the quantity of free DPPC in the airways and gastric aspirates of children with gastroesophageal reflux disease (GORD) to those without and (ii) describe the association between free DPPC levels with airway cellular profile and capsaicin cough sensitivity.
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Keywords: children; cough; gastroesophageal reflux; oesophagitis; surfactant

Document Type: Research Article

Affiliations: Cancer and Population Studies, Queensland Institute of Medical Research, Brisbane, Queensland, Australia

Publication date: April 1, 2006

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