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Visualization of zinc pyrithione particles deposited on the scalp from a shampoo by tape‐strip sampling and scanning electron microscopy/energy dispersive X‐ray spectroscopy measurement

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Zinc pyrithione (ZnPT) is widely used as an anti‐fungal active in commercial anti‐dandruff (AD) shampoos. The AD efficacy of ZnPT is highly dependent on the deposition of ZnPT particles onto the scalp during the process of shampoo application and rinse‐off. Since ZnPT materials with different particle sizes and morphologies have different deposition behaviours, the measurement of the actual ZnPT deposition is critical to understand the AD performance delivered by different ZnPT shampoos. The aim of this study is to develop a robust and reliable method for visualizing the particle size and morphology of ZnPT deposited on the scalp from AD shampoos.
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Keywords: SEM; claim substantiation in vivo/in vitro; delivery/vectorization/penetration; hair treatment (washing, straightening, protection); zinc pyrithione (ZnPT)

Document Type: Research Article

Publication date: October 1, 2018

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