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Disruption of human stratum corneum lipid structure by sodium dodecyl sulphate

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Surfactants are major ingredients of body soaps and cleansers, and such harsh ones have been demonstrated to damage the skin. Stratum corneum (SC), the outermost barrier of the skin layer, is rich in intercellular lipids. This lipid structure can be disrupted by surfactants, impairing the barrier function of the skin. Thus, we investigated the surfactant‐induced disruption of the intercellular lipid structure of human SC at the molecular level using synchrotron X‐ray diffraction.
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Keywords: X‐ray diffraction; chemical analysis; intercellular lipid; lamellar structure; skin barrier; skin physiology/structure

Document Type: Research Article

Publication date: February 1, 2018

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