Skip to main content
padlock icon - secure page this page is secure

Naturally occurring ω‐Hydroxyacids

Buy Article:

$52.00 + tax (Refund Policy)

ω‐Hydroxyacids are fatty acids bearing a hydroxyl group on the terminal carbon. They are found in mammals and higher plants and are often involved in providing a permeability barrier, the primary purpose of which is to reduce water loss. Some ω‐hydroxyacid derivatives may be involved in waterproofing and signalling. The purpose of this review was to survey the known natural sources of ω‐hydroxyacids. ω‐Hydroxyacids are produced by two different P450‐dependent mechanisms. The longer (30–34 carbons) ω‐hydroxyacids are produced by chain extension from palmitic acid until the chain extends across the membrane in which the extension is taking place, and then the terminal carbon is hydroxylated. Shorter fatty acids can be hydroxylated directly to produce C16 and C18 ω‐hydroxyacids found in plants and 20‐eicosatetraenoic acid (20‐HETE) by a different P450. The C16 and C18 ω‐hydroxyacids are components of polymers in plants. The long‐chain ω‐hydroxyacids are found in epidermal sphingolipids, in giant‐ring lactones from the sebum of members of the equidae, as a component of meibum and in carnauba wax and wool wax.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: ceramide; chemical analysis; glucosylceramide; skin barrier; skin physiology/structure

Document Type: Research Article

Publication date: February 1, 2018

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more