Microneedle‐mediated intradermal delivery of epigallocatechin‐3‐gallate
Epigallocatechin‐3‐gallate (EGCG) is the physiologically most active and abundant flavanol, accounting for 50–80% of green tea catechins. It is an anti‐inflammatory, antioxidant, chemopreventive and skin photoprotective agent. However, light sensitivity and low permeability of EGCG across the stratum corneum due to its high molecular weight as well as strong binding to the lipid bilayers in the skin make it difficult to be used as a key ingredient in cosmetic products. This study aimed to formulate a photostable hydrogel of EGCG with good rheological properties for dermal application and investigate the effect of skin microporation using maltose microneedles on its permeation through dermatomed porcine skin.
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