Comparative studies on the chemical and enzymatic stability of alpha‐ and beta‐arbutin
The aim of this study was to establish a comparative analysis of the chemical and enzymatic stability of α‐ and β‐arbutins as potential sources of the substance of concern hydroquinone (HQ). The study was performed using an array of techniques including HPLC‐PDA, nuclear magnetic resonance (NMR) and optical rotation (OR). Both arbutins are emerging as popular and effective skin whiteners, acting as tyrosinase inhibitors in a fashion similar to the popular whitening agent HQ. Due to their structural similarity to the regulated agent HQ, both arbutins may be regarded as potential sources of the active aglycone after chemical or metabolic conversion.
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