Modified Corneosurfametry as a new accelerated high‐throughput ex vivo methodology for predicting cleanser effects towards human skin
Corneosurfametry (CSM) was originally developed as a tool to predict irritation potential of cleansers. In this method, surface skin stripped using cyanoacrylate is contacted with surfactants/products, rinsed and stained with toluidine blue and basic fuschin dyes. The intensity of staining increases with increases in irritation potential of surfactant. Our objective was to modify the CSM technique to achieve better control of the tape stripping process. Another objective was to correlate the modified CSM (MCSM) with a traditional in‐vivo forearm controlled application test (FCAT) for mildness and to explore its utility to assess the state of corneum after a clinical test.
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