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Malva verticillata seed extracts upregulate the Wnt pathway in human dermal papilla cells

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Mesenchymal–epithelial interactions are important in controlling hair growth and the hair cycle. The β‐catenin pathway of dermal papilla cells (DPCs) plays a pivotal role in morphogenesis and normal regeneration of hair follicles. Deletion of β‐catenin in the dermal papilla reduces proliferation of the hair follicle progenitor cells that generate the hair shaft and induces an early onset of the catagen phase. In this study, a modulator of the Wnt/β‐catenin activity was studied in oriental herb extracts on cultured human DPCs.
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Keywords: Malva verticillata seeds; Wnt/β‐catenin; dermal papilla cells; hair growth; myristoleic acid

Document Type: Research Article

Publication date: April 1, 2016

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