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Optimization and development of stable w/o/w cosmetic multiple emulsions by means of the Quality by Design approach

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The aim of our present work was to develop stable water‐in‐oil‐in‐water (w/o/w) cosmetic multiple emulsions that are proper for cosmetic use and can also be applied on the skin as pharmaceutical vehicles by means of Quality by Design (QbD) concept. This product design concept consists of a risk assessment step and also the ‘predetermination’ of the critical material attributes and process parameters of a stable multiple emulsion system. We have set up the hypothesis that the stability of multiple emulsions can be improved by the development based on such systematic planning – making a map of critical product parameters – so their industrial usage can be increased.
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Keywords: Quality by Design concept; droplet size; multiple emulsion; risk assessment; stability; viscosity

Document Type: Research Article

Publication date: April 1, 2016

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