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Simultaneous determination of arbutin and its decomposed product hydroquinone in whitening creams using high‐performance liquid chromatography with photodiode array detection: Effect of temperature and pH on decomposition

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Arbutin is an effective agent for the treatment of melanin disorders. Arbutin may be converted to hydroquinone under conditions of high temperature, ultraviolet (UV) radiation and dilute acid. The aim of the current study was to develop an analytical method to determine the levels of arbutin and hydroquinone in whitening cosmetic products using high‐performance liquid chromatography with photodiode array detection (HPLC‐DAD). In addition, we investigated the effects of high temperature and pH on the decomposition of arbutin.
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Keywords: arbutin; high‐performance liquid chromatography; hydroquinone; temperature; whitening cosmetics

Document Type: Research Article

Publication date: December 1, 2015

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