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Opioid receptor delta as a global modulator of skin differentiation and barrier function repair

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The aims of this study were to confirm the properties of selective agonist peptide (Rubixyl) contained in the spinach towards opioid receptor delta. In fact, agonist properties of both spinach peptides (Rubiscolin‐5 and Rubixyl) towards opioid receptor delta were demonstrated by Zang et al., but their effects on the other opioid receptors were not studied [1]. We also studied the expression of opioid receptor delta in epidermis under normal and stress condition (inflammatory) and its role in epidermis homeostasis under stress condition in vitro and in vivo.
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Keywords: sensitive skin/inflammation/Allergy; skin physiology/structure; skin repair/skin differentiation

Document Type: Research Article

Publication date: August 1, 2015

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