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A comparison between interactions of triglyceride oil and mineral oil with proteins and their ability to reduce cleanser surfactant‐induced irritation

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Skin irritation in personal cleansing has been correlated with surfactant binding with stratum corneum proteins. Polar and non‐polar oils are increasingly being used in cleansing formulations which contain high (10–15%) level of anionic and non‐ionic surfactants. However, the effects of oils in modulating skin damage from a cleansing product have not been studied in any detail. The objectives of this study are to determine whether low‐viscosity polar and non‐polar oils differ in their ability to reduce surfactant‐induced skin irritation and, if so, how it might be related to their interactions with proteins.
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Keywords: EPR/ESR spectroscopy; cleanser‐induced skin irritation; conductivity; oil–corneum protein interaction; surfactant–protein binding

Document Type: Research Article

Publication date: August 1, 2015

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