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PDGF‐AA‐induced filamentous mitochondria benefit dermal papilla cells in cellular migration

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Human dermal papilla cells (HDPCs) play essential roles in hair follicular morphogenesis and postnatal hair growth cycles. Previous reports demonstrated that platelet‐derived growth factor‐AA (PDGF‐AA) enhanced the formation of dermal condensates in hair follicular development. Additionally, PDGF‐AA induces/maintains the anagen phase of the hair cycle. It is likely that mitochondrial morphology and functions are tightly coupled with maintenance of these energy‐demanding activities. However, little is known about the mitochondrial regulation in HDPCs. Thus, we investigated the PDGF‐involved mitochondrial regulation in HDPCs.
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Keywords: ageing; cell culture; hair growth; mitochondria; platelet‐derived growth factor‐AA; skin physiology

Document Type: Research Article

Publication date: June 1, 2015

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