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Anti‐inflammatory and anti‐bacterial properties of tetramethylhexadecenyl succinyl cysteine (TSC): a skin‐protecting cosmetic functional ingredient

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The skin is the first line of defence against exposure to microbial, physical, environmental and chemical insults. In mobilizing a protective response, several different cell types located in our skin release and respond to pro‐inflammatory cytokines ensuring skin homeostasis and health. However, chronic activation of this response eventually causes damage resulting in premature ageing. Diosodium tetramethylhexadecenyl succinyl cysteine (TSC or SIG1273), an isoprenylcysteine small molecule, down modulates these inflammatory signalling pathways in various cell types (keratinocytes, peripheral blood mononuclear cells (PBMCs) and endothelial cells) and possesses anti‐bacterial properties. Thus, TSC represents a novel cosmetic functional ingredient that provides a broad spectrum of benefits for the skin.
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Keywords: claim substantiation in vivo/in vitro; microbiology (skin)/preservation (products); sensitive skin/inflammation/allergy

Document Type: Research Article

Publication date: February 1, 2015

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