Skip to main content
padlock icon - secure page this page is secure

Zinc l‐pyrrolidone carboxylate inhibits the UVA‐induced production of matrix metalloproteinase‐1 by in vitro cultured skin fibroblasts, whereas it enhances their collagen synthesis

Buy Article:

$52.00 + tax (Refund Policy)


Reduced collagen matrix in the dermis constitutes one of the characteristic features of chronologically aged skin, which is further enhanced on the sun‐exposed portions of the body by chronic ultraviolet light (UV) irradiation, inducing the unique changes associated with skin photoageing. The zinc salt of l‐pyrrolidone carboxylate (Zinc PCA) has long been used as a cosmetic ingredient, because of its astringent and anti‐microbial properties. In the present study, by employing cultured normal human dermal fibroblasts, we found that Zinc PCA suppressed UVA‐induced activation of activator protein‐1 (AP‐1) and reduced matrix metalloproteinase‐1 production in these cells, which is thought to be involved in collagen degradation in photoaged skin. Moreover, Zinc PCA treatment of the cells increased the expression of an ascorbic acid transporter mRNA, SVCT2, but not SVCT1, resulting in the enhanced production of type I collagen. Based on these in vitro findings, we consider Zinc PCA to be a promising candidate for an anti‐skin ageing agent.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Language: English

Document Type: Research Article

Affiliations: 1: Ajinomoto Co., Inc., Research Institute for Bioscience Products & Fine Chemicals, 1-1, Suzuki-cho, Kawasaki-ku, Kawasaki-shi 210-8681 2: Ajinomoto Co., Inc., Institute for Innovation, 1-1, Suzuki-cho, Kawasaki-ku, Kawasaki-shi 210-8681 3: Tohoku University School of Medicine, Sendai, Japan

Publication date: February 1, 2012

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more