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Improvement of facial skin characteristics using copper oxide containing pillowcases: a double-blind, placebo-controlled, parallel, randomized study

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Synopsis Copper plays a key role in several processes of skin formation and regeneration. Copper has been shown to be absorbed through intact skin. We hypothesized that sleeping on fabrics containing copper-impregnated fibres would have a positive cosmetic effect on the skin. The aim of this study was to confirm our hypothesis. A 4-week, double blind, parallel, randomized study was carried out in which 57 volunteers aged 40–60 years used either copper oxide containing pillowcases (0.4% weight/weight) or control pillowcases not containing copper. Photographs were taken by a professional photographer of each participant at the beginning of the study and at 2 and 4 weeks after the commencement of the study. Two expert graders (a dermatologist and a cosmetologist) evaluated the pictures for the effect on several cosmetic facial skin characteristics. The copper-containing pillowcases had a positive effect for the following facial characteristics: reduction of wrinkles ( < 0.001) and crow’s feet/fine lines ( < 0.001) and improvement of general appearance ( < 0.001) at both 2 and 4 weeks. The differences were statistically significant (Wilcoxon scores and chi-squared tests). Consistent sleeping for 4 weeks on copper oxide containing pillowcases caused a significant reduction in the appearance of facial wrinkles and crow’s feet/fine lines and significant improvement in the appearance of facial skin. In most trial participants, this effect was already noticeable within 2 weeks of using the copper oxide containing pillowcases.

French
Résumé

Le cuivre jout un rôle significatif dans quelleques processus de la formation et la régénération de la peau. Le cuivre était montré d’être absorbéà travers la peau intacte. Nous avons suppose que le sommeil sur les tissus containent les fibres imprégnées par le cuivre auraient un effet cosmétique positif sur la peau. Le but de cette étude etait de confirmer nôtre hypothèse. Une étude de 4 semaines double-aveugle, parallèle, et al.éatoire etait executée, dans laquelle 55 volontairs, agés 40–60 ans, avaient utilizé soit les taies d’oreiller containent l’oxide de cuivre (0.4% poids/poids) soit les taies d’oreiller controles qui ne containent pas du cuivre. Chaque participant etait pris en photo par un photographe professional au debut de l’étude et au point de 2 et 4 semaines après le debut de l’étude. Deux correcteurs experts (un dermatologue et un cosmetologue) ont évalué les photos pour l’effet sur plusieures characteristiques faciales cosmétiques. Les taies d’oreilleur containent le cuivre ont eu un effet positif pour les characteristiques faciales suivantes: la réduction de rides (P < 0.001) and et pattes d’oie/lignes fines (P < 0.001) et l’amélioration de l’apparence generale (P < 0.001), au point de 2 et 4 semaines. Le sommeil sur les taies d’oreiller containent l’oxide de cuivre a causé une reduction significative dans l’apparence de rides facials et pattes d’oie/lignes fines et une amelioration significative dans l’apparence de la peau faciale. Dans la plupart des participants, cet effet était déjà visible dans 2 semaines après l’utilisation des taies d’oreiller containent l’oxide de cuivre.
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Keywords: clinical study; copper oxide; pillowcases; textile; wrinkles

Document Type: Research Article

Affiliations: 1: Cupron Inc., 4 Ha’Oman Street, North Industrial Area, Beth Shemesh, Israel 2: Department of Dermatology, Sheba Medical Center, Tel Aviv 3: Department of Pathology, Kaplan Medical Center, Rehovot, Israel

Publication date: December 1, 2009

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