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Oat-based complex stimulates skin barrier protein synthesis and reduces skin ageing

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Citation: IFSCC Magazine, 11 (2008) (3) 217–223

Epidermal differentiation is crucial to guarantee a physiological cornification process. The cornified envelope is the final skin barrier which protects against external aggressions such as UV light and reduces water loss. Skin ageing is associated with decreased functionality of this barrier and reduced epidermal differentiation. We present a new bioactive complex for the stimulation of protein synthesis associated with cornified envelope and markers of epidermal differentiation. Composed of a hydrolyzed oat protein extract and particularly rich in glutamine and glutamic acid combined with ATP and niacinamide, 1% of this complex increases significantly the synthesis of proteins such as filaggrin, late envelope protein and small proline-rich proteins, all markers of epidermal differentiation, in a reconstituted human skin model as measured by DNA array chip analysis, reverse transcription-polymerase chain reaction and immunohistochemistry. When a cream containing 3% of this bioactive complex was applied to the skin of 25 human volunteers, an increase in skin hydration of more than 60% after 14 days of application and a reduction of wrinkles and roughness by more than 50% in 4 weeks were observed compared with a placebo cream. In conclusion, the bioactive complex stimulated synthesis of proteins which are important for epidermal differentiation and skin barrier function and was helpful in fighting skin ageing. Keywords: 

Hydrolyzed oat protein extract, cornified envelope, filaggrin, small proline-rich proteins, skin barrier, anti-ageing
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Document Type: Abstract

Affiliations: 1: Induchem AG, Industriestrasse 8a, Volketswil, Switzerland 2: Dellacqua Consultant, Switzerland

Publication date: October 1, 2009

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