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Role of topical peptides in preventing or treating aged skin

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Synopsis Ageing, a basic biological process seen in all living creatures, is not preventable. Surgical and topical modalities have been invented and substances were applied topically to alter the ageing process. Peptides and proteins, frequently used for this purpose, were categorized into four groups: signal peptides, enzyme-inhibitor peptides, neurotransmitter-inhibitor peptides and carrier peptides. We comprehensively review eligible studies -including controlled or efficacy studies on any topical peptide or protein that has been administered to treat signs and symptoms of ageing.


Le vieillissement, processus biologique concernant toutes les créatures vivantes est inévitable. Divers moyens chirurgicaux et topiques ont été inventés et plusieurs substances ont été appliquées pour modifier ce processus. Les peptides et les protéines fréquemment utilisés dans ce but sont regroupés en 4 catégories : les peptides signaux, les peptides inhibiteurs enzymatiques, les peptides inhibiteurs de neurotransmetteurs et les peptides transporteurs. Nous passons en revue les études recevables – y compris les études d’efficacitéex vivo ou in vivo– concernant les peptides ou les protéines mis en œuvre pour traiter les symptômes et les signes du vieillissement.
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Keywords: cosmetics; elderly; peptides; percutaneous penetration; proteins

Document Type: Review Article

Publication date: October 1, 2009

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