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Spectrofluorimetric determination of tranexamic acid in hydrogel patch formulations by derivatization with naphthalene-2, 3-dicarboxaldehyde/cyanide

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The aim of this research was to develop and validate a spectrofluorimetric method for determination of tranexamic acid in hydrogel patch formulations. Tranexamic acid (trans-4-aminomethylcyclohexanecarboxylic acid, trans-AMCHA) is an antifibrinolytic drug that recently gained attention as a skin-whitening agent due to its inhibitory effect on ultraviolet (UV)-induced pigmentation in vivo. Derivatization with naphthalene-2, 3-dicarboxaldehyde (NDA) in the presence of cyanide ion (CN-) to produce a fluorescent 1-cyanobenz[f]isoindole (CBI) product (?ex = 420 nm, ?em = 480 nm) [[Au: Please check the symbol.]] is for the first time reported for the determination of tranexamic acid in hydrogel patch formulations. Other separation techniques were not used in the analysis of the CBI-fluorescent product as required in the previous studies. The developed method was proven to be precise and accurate with percent recoveries ranging between 98.0% and 101.8% at the concentration range of 8.4–84.0 μg/ml (R2 > 0.999). The intra-and inter-day precisions as expressed by the relative standard deviations (RSD) were below 1.85%. Derivatization of tranexamic acid with NDA/CN-was completed within 5 min and was stable for at least 30 min. The method has been applied to the analysis of drug content and release profiles in tranexamic hydrogel patch formulations.
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Document Type: Abstract

Publication date: August 1, 2008

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