Skip to main content
padlock icon - secure page this page is secure

Spectrofluorimetric determination of tranexamic acid in hydrogel patch formulations by derivatization with naphthalene-2, 3-dicarboxaldehyde/cyanide

Buy Article:

$52.00 + tax (Refund Policy)

The aim of this research was to develop and validate a spectrofluorimetric method for determination of tranexamic acid in hydrogel patch formulations. Tranexamic acid (trans-4-aminomethylcyclohexanecarboxylic acid, trans-AMCHA) is an antifibrinolytic drug that recently gained attention as a skin-whitening agent due to its inhibitory effect on ultraviolet (UV)-induced pigmentation in vivo. Derivatization with naphthalene-2, 3-dicarboxaldehyde (NDA) in the presence of cyanide ion (CN-) to produce a fluorescent 1-cyanobenz[f]isoindole (CBI) product (?ex = 420 nm, ?em = 480 nm) [[Au: Please check the symbol.]] is for the first time reported for the determination of tranexamic acid in hydrogel patch formulations. Other separation techniques were not used in the analysis of the CBI-fluorescent product as required in the previous studies. The developed method was proven to be precise and accurate with percent recoveries ranging between 98.0% and 101.8% at the concentration range of 8.4–84.0 μg/ml (R2 > 0.999). The intra-and inter-day precisions as expressed by the relative standard deviations (RSD) were below 1.85%. Derivatization of tranexamic acid with NDA/CN-was completed within 5 min and was stable for at least 30 min. The method has been applied to the analysis of drug content and release profiles in tranexamic hydrogel patch formulations.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Document Type: Abstract

Publication date: August 1, 2008

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more