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Stabilization and release profile of retinol and tocopherol with microcapsules based on chitosan

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The incorporation of unstable cosmetic actives such as retinol into formulations requires methods of stabilization to ensure their long-term activity and efficacy. A delivery system entrapping lipophilic vitamins such as retinol and tocopherol based on chitosan coacervation with negative polymers is described in this paper. The microcapsules appear to be spherical with a narrow particle size distribution, not aggregated, and with a homogeneous surface. Microencapsulation with such a system prolongs the active's life in skin care O/W formulations by at least one order of magnitude in the tested formulas. Furthermore, the biodegradation profile of this delivery system is consistent with a sustained release profile in human epidermis.
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Document Type: Abstract

Publication date: February 1, 2008

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