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Formulation, characterization, and efficacy of an adenosine-containing dissolvable film for a localized anti-wrinkle effect

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A water-dissolvable film was developed to topically deliver adenosine for a localized anti-wrinkle effect. The polymers used to produce the film were cellulose derivatives. An aqueous mixture of the film components was made, coated on a liner, and then dried to form a solid film. No preservatives were added and the film was shown to be stable over time. The film quickly dissolves in water to form a uniform layer at the surface of the skin, as shown by scanning electron microscopy. The film layer can still be visualized on the wrinkle 6 h after being applied on the skin. A randomized, placebo-controlled, investigator-blind study was conducted in female volunteers to assess the efficacy of the 1% adenosine-containing dissolvable film. After 3 weeks and 8 weeks, a twice daily application led to a significant decrease in the skin roughness parameters as observed using fast optical in vivo topometry (FOITS). These results demonstrate that water-dissolvable films may be used as novel, preservative-free, cosmetic delivery systems.
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Document Type: Abstract

Affiliations: 1: L’Oréal Recherche, 188–200 rue Paul Hochart, 94550 Chevilly-Larue, 2: Skin Care Systems, Lohmannstrasse 2, 56626 Andernach, Germany 3: 1 av Eugène Schueller, 93601 Aulnay-sous-Bois, France and

Publication date: February 1, 2008

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