Skip to main content
padlock icon - secure page this page is secure

Blackberry leaf extract: a multifunctional anti-aging active

Buy Article:

$52.00 + tax (Refund Policy)

Matrix metalloproteinases (MMPs) play a major role in wrinkle formation. Their expression increases with aging and is further enhanced by UV irradiation. Blackberry (Rubus fruticosus) leaf extract has been shown to suppress MMP-1, -2 and -9 in cell-free assays. We have now further explored the activity of this extract. The effect on MMP-1 expression at the protein and the mRNA level was investigated using non-irradiated and UVA-irradiated human dermal fibroblasts. The extract showed a dose-dependent reduction of the MMP-1 protein level of both irradiated and non-irradiated cells with an almost complete inhibition at a dosage of 0.1%. MMP-1 mRNA expression of UVA-irradiated cells was decreased after pre-incubation as well as after post-incubation with the extract. Best results were obtained with combined pre- and post-treatment (0.1% extract led to 59% reduction in comparison with the respective control). Moreover, we found that blackberry leaf extract inhibits IL-1α, a cytokine known to induce MMP expression. At a dosage of 0.2% the inhibition was 40% compared with that of the stimulated control. The extract also exhibited a potent radical scavenging activity comparable to that of α-tocopherol as was shown by the ABTS assay. Taken together, these biological activities make blackberry leaf extract a highly efficient multifunctional anti-aging active.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Document Type: Abstract

Affiliations: 1: Symrise GmbH & Co KG, Research Cosmetic Ingredients, Mühlenfeldstr. 1, 37603 Holzminden, Germany 2: Environmental Health Research Institute, Auf’m Hennekamp 50, 40225 Düsseldorf, Germany

Publication date: October 1, 2007

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more