Skip to main content
padlock icon - secure page this page is secure

Fragrance raw materials and essential oils can reduce prostaglandin E2 formation in keratinocytes and reconstituted human epidermis

Buy Article:

$52.00 + tax (Refund Policy)


Essential oils and certain perfumery raw materials exhibit a wide range of beneficial biological activities. Besides the antimicrobial and antioxidant activity, the anti-inflammatory and anti-irritant effects are most often cited. One specific mode of action is the reduction of the formation of the key mediator prostaglandin E2 (PGE2). To study this activity in detail and to create cosmetically useful fragrances with the potential to reduce a key marker of skin irritancy in keratinocytes, an initial screening with pig blood platelets was conducted on 900 perfumery raw materials. Active compounds were then validated in a human keratinocyte cell line. Compounds which successfully reduced PGE2 formation in this assay were used for the creation of active fragrances. These final fragrances reduced PGE2 formation by >80% when dosed at 0.8 μg mL−1 to keratinocytes. Application of such a fragrance in a hydrogel allowed reduction of UVB-induced PGE2 formation in reconstituted epidermis (MatTec EpiDermTM). Similarly, antiperspirant-induced formation of PGE2 in reconstituted epidermis was reduced to background levels if these novel fragrances were used in the antiperspirant formulation. In conclusion, fragrances with this added cosmetic benefit can be created based on a database from a comprehensive screening. These fragrances may find use as a part of a formulation strategy optimizing each part of a cosmetic formulation for optimal product mildness.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: anti-irritant activity; essential oils; fragrance; keratinocytes; prostaglandins; reconstituted epidermis

Document Type: Research Article

Publication date: October 1, 2007

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more