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Protective effects of taurine on human hair follicle grown in vitro

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Synopsis Taurine is a naturally occurring -amino acid produced by methionine and cysteine metabolism. It is involved in a variety of physiological functions, including immunomodulatory and antifibrotic. Taking advantage of the ability of human hair follicle grown to recapitulate most of the characteristic features of normal hair follicle , we studied (i) taurine uptake by isolated human hair follicles; (ii) its effects on hair growth and survival rate; and (iii) its protective potential against transforming growth factor (TGF)-1, an inhibitor of hair growth and a master switch of fibrotic program. We showed that taurine was taken up by the connective tissue sheath, proximal outer root sheath and hair bulb, promoted hair survival and prevented TGF-1-induced deleterious effects on hair follicle.

French
Résumé

La taurine est un β-amino acide naturel qui dérive du métabolisme de la méthionine et de la cystéine. Elle est impliquée dans un grand nombre de fonctions physiologiques, et présente en particulier des activités immuno-modulatrices et antifibrotiques. En s'appuyant sur le modèle du follicule pileux in vitro, qui reproduit de nombreuses caractéristiques du follicule normal in vivo, nous avons étudié (i) l'incorporation et la distribution de la taurine dans un follicule pileux isolé, (ii) son effet sur la croissance et la survie du follicule et (iii) son rôle protecteur vis-à-vis du TGF-β1, à la fois inhibiteur de la croissance du follicule et inducteur du programme fibrotique. Nous montrons que la taurine est captée par la gaine conjonctive, la gaine externe proximale et le bulbe, assure la survie du follicule in vitro et s'oppose à l'effet délétère du TGF-β1 sur le follicule pileux.
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Keywords: in vitro hair growth; taurine; transforming growth factor-β1

Document Type: Research Article

Affiliations: 1: Clichy et 2: Aulnay-sous-bois, France

Publication date: August 1, 2006

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