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Quantitative determination of formaldehyde in cosmetics using combined headspace–solid-phase microextraction chromatography

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The objective of this research was the application of headspace (HS)–solid-phase microextraction (SPME) for quantitation of formaldehyde present in raw materials and cosmetic formulations. The formaldehyde was derivatized in situ first with pentafluorophenylhydrazine (PFPH), to form a derivative hydrazone. The hydrozone was adsorbed on a SPME fiber during headspace extraction under controlled conditions (temperature, volume, etc.). After the adsorption step, the SPME fiber was directly transferred into the chromatography (GC) injection port, in which the analytes were thermally desorbed. Deuterated acetone is regarded as an internal standard (IS) in order to quantitate the formaldehyde content. For the experiment, chromatograph equipped with a flame ionization detector (GC/FID) was employed. A gas chromatograph/mass spectrometer (GC/MS) was used for the qualitative confirmation of results in this work.
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Document Type: Abstract

Publication date: December 1, 2004

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