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The stabilization ofL-ascorbic acid in aqueous solution and water-in-oil-in-water double emulsion by controlling pH and electrolyte concentration

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This study presents a new approach that can stabilize effectivelyl-ascorbic acid in water-in-oil-in-water (w/o/w) double emulsions. Basically, the behavior ofl-ascorbic acid in the aqueous phase was observed, considering its molecular deformation. Then, it was found that the stability determined in the aqueous phase by high-performance liquid chromatography (HPLC) showed that the collapse of ionization ofl-ascorbic acid played a crucial role in protecting the molecular deformation. Then, the stable aqueous system was incorporated into the internal aqueous phase of the double emulsions. From the PLC analysis, it was observed that thel-ascorbic acid in an appropriate system showed high molecular stability for a long time. Moreover, in the measurement of in vitro skin permeation, thel-ascorbic acid stabilized in this study showed considerable skin permeation ability, indicating its potential applicability in pharmaceutics and cosmetics.
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Document Type: Abstract

Affiliations: 1: Amore Pacific Corporation R&D Center, 314-1 Bora-ri, Giheung-eup, Yongin-si, Gyeonggi-do 449-729, Korea 2: Division of Chemical Engineering, College of Engineering, Hanyang University, Seoul 133-791, Korea

Publication date: August 1, 2004

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