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Progress report on hair keratin research

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Synopsis Evidence is given for the progress in hair keratin research by bringing out four examples from the recent hair science literature. • Kon . [ 1] published a new method of solubilization and fractionation of the matrix and the microfibril proteins and found a significant decrease in the ‘intact’ microfibril keratin at the tip end of permed hair. • Contrary to the previous view of the existence of four major and one minor hair keratin pair, Langbein . [ 2, 3] showed that there are nine type I hair keratins and six type II hair keratins and drew up a two-dimensional catalogue of human hair keratins. • To collectively describe the extremely complex expression pattern of human type I and type II hair keratins in the hair follicle, Langbein . [ 2, 3] have summarized the corresponding RNA expression profiles of the various hair keratins schematically. • Contrary to the previous assignment of keratins exclusively to the microfibrils in the cortex, the mRNA expression studies of Langbein . [ 2, 3] implied that any hair cuticle cell leaving the living cell compartment contains four different hair keratins.

French
Résumé

Les progrès de la recherche sur les kératines du cheveu humain sont décrits en commentant quatre exemples tirés de la littérature scientifique récente:
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Keywords: keratin; keratin genes; microfibrils; protein studies; wool research

Document Type: Research Article

Publication date: June 1, 2002

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