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Prolonged effects of antidandruff shampoos ‐ time to recurrence of Malassezia ovalis colonization of skin

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Most active antidandruff shampoos exhibit a strong activity against the yeast Malassezia ovalis. The present study was undertaken to compare the prolonged antifungal effect of three proprietary shampoos containing either 2% ketoconazole, 1.5% zinc pyrithione or 2.5% selenium sulphide. Superficial squames were harvested from the scalp in the days following a 6‐week antifungal shampoo treatment. Counts of yeasts highlighted by a fluorochrome were made using computerized image analysis. Data show the increased duration of yeast reduction for the ketoconazole shampoo over the two other formulations. The lingering effect of ketoconazole is explained by the combination of its antifungal and pharmacokinetic properties. Resume. La plupart des shampooings anti‐pelliculaires exercent une activite importante a l'encontre de la levure Malassezia ovalis. La presente etude a ete entreprise pour comparer l'effet antifongique remanent de trois shampooings commerciaux contenant 2% de ketoconazole, 1.5% de pyrithione de zinc ou 2.5% de sulfure de selenium. Des comptes de levures revelees par un fluorochrome furent realises par analyse informatisee d'images a partir d'echantillons collectes sur le cuir chevelu dans les jours suivant l'arret de 6 semaines de traitement par l'un des shampooings antifongiques. Les resultats montrent que le temps necessaire pour la recolonisation par les levures est plus long apres utilisation du shampooing contenant le ketoconazole par rapport aux autres formulations. L'effet remanent du ketoconazole est explique par la combinaison de ses proprietes antifongiques et pharmacocinetiques.
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Document Type: Research Article

Affiliations: 1: University of Liege, Department of Dermatopathology, CHU Sart Tilman Liege Belgium 2: Janssen Research Foundation Beerse Belgium

Publication date: June 1, 1997

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