Protective effects of avocado and soya bean lipidic non‐saponifiables on proliferation of fibroblasts cultured in altered conditions

Non‐saponifiables lipidic fraction of avocado and soya bean (PIAS) induces, when administered percutaneously, a stimulation of specific metabolism of fibroblasts (synthesis of soluble collagen, increase of the ratio soluble collagen/insoluble collagen). In investigating the mechanism through which unsaponifiables affect the fibroblast metabolism we studied their direct effect on proliferation and survival of human fibroblasts cultured in optimal and altered conditions.