Skip to main content
padlock icon - secure page this page is secure

Molecular Pharmacology of Topiramate: Managing Seizures and Preventing Migraine

Buy Article:

$52.00 + tax (Refund Policy)

Topiramate is a neuromodulatory compound with stabilizing properties that was initially introduced for the management of partial seizures. Topiramate has been demonstrated to modify several receptor-gated and voltage-sensitive ion channels, including voltage-activated Na+ and Ca2+ channels and non-NMDA receptors. These receptors have been implicated in the pathophysiology of both epilepsy and migraine. The pharmacological mechanisms of action for topiramate that may explain its antiepileptic and migraine preventive activities will be discussed in this review. In addition, the potential relationship between the molecular activities of topiramate and its efficacy in epilepsy and migraine prevention will be emphasized.

(Headache 2005;45[Suppl 1]:S48-S56)
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: epilepsy; migraine; prevention; topiramate; voltage-gated channels

Document Type: Research Article

Publication date: April 1, 2005

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more