Skip to main content
padlock icon - secure page this page is secure

Familial Migraine With Aura: Association Study With 5-HT1B/1D, 5-HT2C, and hSERT Polymorphisms

Buy Article:

$52.00 + tax (Refund Policy)

Background.—The serotonergic system has a significant role in the pathophysiology and pharmacology of migraine.

Objective.—To study the association between the occurrence of migraine with aura and 5-HT1B/1D and 5-HT2C receptor gene and the human serotonin transporter (hSERT) gene polymorphisms in 18 unrelated families with multiple affected members.

Method.—Two polymorphisms in the 5-HT1B/1D receptor gene and one polymorphism in the 5-HT2C receptor gene were studied by restriction fragment length polymorphism analysis. Allelic variation of the hSERT, with 9, 10, and 12 copies of a “repetitive element,” was studied by polymerase chain reaction amplification of the variable number tandem repeat region.

Results.—Allelic distribution of 5-HT1B/1D and 5-HT2C receptor gene polymorphisms in affected patients did not differ in either of the control groups (unaffected relatives or unrelated healthy individuals). A trend toward a significant effect of the 12-repeat hSERT allele as a risk factor for migraine with aura versus unrelated controls was observed.

Conclusion.—Our data do not support the involvement of 5-HT1B/1D and 5-HT2C receptor gene polymorphisms in migraine with aura, yet do suggest a possible role for a locus at or near the hSERT gene in the susceptibility to migraine with aura.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: aura; migraine; polymorphism; serotonin receptor; serotonin transporter

Document Type: Research Article

Publication date: April 1, 2004

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more