Skip to main content
padlock icon - secure page this page is secure

Free Content A Prospective Study of the Incidence of the Purple Glove Syndrome

Download Article:

You have access to the full text article on a website external to Ingenta Connect.

Please click here to view this article on Wiley Online Library.

You may be required to register and activate access on Wiley Online Library before you can obtain the full text. If you have any queries please visit Wiley Online Library

Summary:  Purpose:

Phenytoin (PHT) has been widely used intravenously for the treatment of seizures since 1956, and for many years, it has been considered first-line therapy for status epilepticus. It is routinely administered intravenously in emergency departments and hospitals for patients who have had isolated seizures and for many patients undergoing neurosurgical procedures who are unable to receive oral medication. Adverse reactions from PHT have been widely studied for years, but in the past decade, new adverse reactions have been identified. One of these adverse reactions is the purple glove syndrome (PGS), characterized by edema, discoloration, and pain distal to the site of i.v. administration of PHT. Because there have been no prospective reports of the incidence of PGS, the objective of the study was to report the incidence of this syndrome. Methods:

We enrolled 179 consecutive exposures to i.v. PHT at Henry Ford Hospital. Distal portions of the upper extremities were examined and digitally photographed by one of the authors (J.G.B.). The photos were blindly evaluated by the third author (G.L.B.) for PGS. Demographic and pertinent medical history was recorded for all patients, and outcome for those who experienced PGS was recorded. Associations between PGS, demographic, and medical history information were assessed. Results:

In only three of the 179 exposures did PGS develop. In both patients, the severity of the clinical picture was mild and did not required prolonged hospitalization or specialized treatment. Conclusions:

PGS is an infrequent and mild adverse effect of i.v. PHT administration.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Adverse reaction; Phenytoin; Purple glove syndrome; Status epilepticus

Document Type: Research Article

Affiliations: 1: UAB Epilepsy Center, University of Alabama at Birmingham, Birmingham, AL, 2: Department of Pharmacy, Henry Ford Health System, and 3: Department of Neurology, Henry Ford Health System and Case Western Reserve University, Detroit, Michigan, U.S.A.

Publication date: September 1, 2001

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more