Skip to main content
padlock icon - secure page this page is secure

Circulating insulin-like growth factor I and functional recovery from spinal cord injury under enriched housing conditions

Buy Article:

$47.00 + tax (Refund Policy)


Voluntary locomotor training as induced by enriched housing of rats stimulates recovery of locomotion after spinal cord injury (SCI). Generally it is thought that spinal neural networks of motor- and interneurons located in the ventral and intermediate laminae within the lumbar intumescence of the spinal cord, also referred to as central pattern generators (CPGs), are the ‘producers of locomotion’ and play a pivotal role in the amelioration of locomotor deficits after SCI. It has been suggested that locomotor training provides locomotor-specific sensory feedback into the CPGs, which stimulates remodeling of central nervous system pathways, including motor systems. Several molecules have been proposed to potentiate this process but the underlying mechanisms are not yet known. To understand these mechanisms, we studied the role of insulin-like growth factor (IGF) I in functional recovery from SCI under normal and enriched environment (EE) housing conditions. In a first experiment, we discovered that subcutaneous administration of IGF-I resulted in better locomotor recovery following SCI. In a second experiment, detailed analysis of the observed functional recovery induced by EE revealed full recovery of hindlimb coordination and stability of gait. This EE-dependent functional recovery was attenuated by alterations in the pre-synaptic bouton density within the ventral gray matter of the lumbar intumescence or CPG area. Neutralization of circulating IGF-I significantly blocked the effectiveness of EE housing on functional recovery and diminished the EE-induced alterations in pre-synaptic bouton density within the CPG area. These results support the use of IGF-I as a possible therapeutic aid in early rehabilitation after SCI.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: central pattern generator; enriched environment; exercise; gait analysis; rat

Document Type: Research Article

Affiliations: 1: Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Utrecht, the Netherlands 2: Department of Physiological Science, Division of Neurosurgery, UCLA Brain Injury Research Center and Brain Research Institute, Los Angeles, CA, USA 3: Laboratory of Neuroendocrinology, Cajal Institute, Consejo Superior de Investgaciones CientÍficas, Madrid, Spain 4: Department of Anesthesiology, Academic Hospital Maastricht, Maastricht, the Netherlands

Publication date: 01 February 2006

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more