In the present study we determined the HLA-A, B and DR antigenic and haplotypic frequencies in unrelated Brazilian Caucasian paediatric patients with IgA deficiency (IgA-D). Out of 17 IgA-D subjects typed for HLA A and B specificities, 12 (71%) presented B8 and/or B14; of 15 patients also typed for HLA-DR specificities, 14 (93%) were positive for at least one of the HLA markers previously reported to be associated with IgA-D, i.e. B8, B14, DR1, DR3 or DR7. The haplotypes B8, DR3, B14, DR1 and B13, DR7 were present in 43, 21 and 14% of the cases, respectively, while they have a frequency in the general population of 2, 2 and 1%, respectively. The concomitant association with the three IgA-associated haplotypes found in our study probably reflects the admixture of European genetic influences present in the Brazilian Caucasian population of São Paulo.
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Document Type: Short Communication
Laboratório de Imunologia Clínica, Departamento de Pediatria, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil,
Instituto da Criança do Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil, and,
Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brasil.
Publication date: August 1, 1998