Skip to main content
padlock icon - secure page this page is secure

The effect of cholesterol lowering on carotid and femoral artery wall stiffness and thickness in patients with familial hypercholesterolaemia

Buy Article:

The full text article is temporarily unavailable.

We apologise for the inconvenience. Please try again later.

Background

Early in the process of atherosclerosis, changes in vessel wall stiffness and thickness may occur. The present study evaluates the effect of cholesterol reduction on artery wall stiffness and intima media thickness in patients with familial hypercholesterolaemia (FH).Materials and methods

Forty-five patients with familial hypercholesterolaemia (mean age 46 ± 10 years) with untreated LDL cholesterol concentration > 9 mmol L-1, were studied before and after one year of cholesterol lowering therapy with statins (simvastatin, atorvastatin 40–80 mg day-1). The distensibility (DC in 10-3 kPa-1) and compliance (CC in mm2. kPa-1) of the common carotid artery (CCA) (right and left side) and common femoral artery (CFA) (right side) were determined by a wall track system (Pie Medical). The intima media thickness (IMT) (both right and left) of the CCA, bulb (BUL), internal carotid artery (ICA) and CFA were measured in mm by high-resolution ultrasound (Biosound).Results

The mean concentration of total cholesterol (TC), LDL-cholesterol (LDL-C) and triglycerides (TG) were reduced significantly by 43%, 51% and 25%, respectively, whereas HDL-cholesterol (HDL-C) increased by 13% (P < 0.001). In the CFA, the DC and CC increased significantly (DC from 7.9 ± 3.0 to 9.1 ± 3.7 in 10-3 kPa-1; CC 0.5 ± 0.2–0.6 ± 0.3 in mm2. kPa-1), whereas the DC and CC did not change in the CCA. In contrast, the IMT of the CCA decreased significantly in both men and women whereas an IMT decrease was also seen in the BUL and ICA in premenopausal women. A LDL-cholesterol reduction of 44.8% and 45.4% was necessary to induce significant decreases in IMT and increases in DC and CC.Conclusions

One year of cholesterol lowering therapy in FH decreases the wall stiffness in the CFA and the arterial wall thickness in the CCA.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Artery wall stiffness; familial hypercholesterolaemia; intima-media thickness

Document Type: Research Article

Affiliations: 1: University Hospital Nijmegen, Nijmegen 2: Academic Medical Center, Amsterdam, the Netherlands

Publication date: June 1, 2000

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more