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Typical cluster headache caused by granulomatous pituitary involvement

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Favier I, Haan J, van Duinen SG & Ferrari MD. Typical cluster headache caused by granulomatous pituitary involvement. Cephalalgia 2007; 27:173–176. London. ISSN 0333-1024

A young woman had typical cluster headache attacks and a pituitary mass lesion. The headache attacks resolved after transsphenoidal resection of the tumour, which was diagnosed as a granulomatous inflammation. The association between cluster headache and granulomatous enlargement of the pituitary gland has never been described before. This case reinforces the growing evidence that even in typical cases of cluster headache, neuroimaging is mandatory to exclude structural lesions.
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Keywords: Cluster headache; granulomatous inflammation; pituitary

Document Type: Research Article

Affiliations: 1: Department of Pathology, Leiden University Medical Centre, Leiden, the Netherlands 2: Department of Neurology, Leiden University Medical Centre, Leiden, the Netherlands,

Publication date: February 1, 2007

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