Skip to main content
padlock icon - secure page this page is secure

Lack of association between the 3092 T→C Clock gene polymorphism and cluster headache

Buy Article:

$52.00 + tax (Refund Policy)

Rainero I, Rivoiro C, Gallone S, Valfrè W, Ferrero M, Angilella G, Rubino E, De Martino P, Savi L, Lo Giudice R & Pinessi L. Lack of association between the 3092 T→C Clock gene polymorphism and cluster headache. Cephalalgia 2005. London. ISSN 0333-1024

Recent studies suggested that genetic factors play a role in cluster headache (CH). However, the type and the number of genes involved in the disease are still unclear. We performed an association study in a cohort of Italian CH patients to evaluate whether a particular allele or genotype of the Clock gene would modify the occurrence and the clinical features of the disease. One hundred and seven CH patients, diagnosed according to the International Classification of Headache Disorders, 2nd Edition, (ICHD-II) criteria, and 210 healthy age, sex and ethnicity-matched controls were genotyped for the 3092 T→C Clock gene polymorphism (also known as 3111 T→C). Phenotype and allele frequencies were similarly distributed in CH patients and controls. The clinical features of the disease were not significantly influenced by different genotypes. In conclusion, our study suggests that the 3092 T→C polymorphism of the Clock gene is unlikely to play an important role in cluster headache.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: 3092 T→C polymorphism; Clock gene; cluster headache; genetic association study; periodicity

Document Type: Research Article

Affiliations: 1: Neurology III, Headache Centre, Department of Neuroscience 2: SCDU, Medical Genetics, University of Torino, Torino, Italy

Publication date: November 1, 2005

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more