Skip to main content
padlock icon - secure page this page is secure

Homogeneous orthogonal diffusion of drugs in the rat brain

Buy Article:

$52.00 + tax (Refund Policy)

The study introduced a homogeneous orthogonal diffusion model to describe the diffusion pattern of agents in the rat brain. Magnetic resonance imaging was performed post‐injection of paramagnetic drugs into the caudatum of the rat brain at predetermined time intervals. The signal intensity on magnetic resonance images was converted to agents’ concentration, and the standard least square method was employed to estimate the diffusion coefficients. The diffusion coefficients calculated along the three orthogonal axes were D 1 = (0.0097 ± 0.0036) mm2/h, D 2 = (0.0153 ± 0.0033) mm2/h, and D 3 = (0.0293 ± 0.0155) mm2/h; the clearance rate constant was = (0.2177 ± 0.0112)/h. The theoretical homogeneous orthogonal model can enhance our knowledge on both the biophysical characteristics of brain extracellular space and the interstitial drug delivery in the brain.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: diffusion; extracellular space; magnetic resonance imaging; mathematical model

Document Type: Research Article

Publication date: April 1, 2019

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more