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Aging mechanisms and intervention targets

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Premature aging occurs frequently to various tissues and organs resulting in the tissue‐specific chronic diseases. The mechanisms of tissue‐specific premature aging are largely unknown. In response to environmental cues, aging may originate from cytoplasm or the nucleus of a cell with cytoplasm aging in association with organelle degeneration in terminally differentiated cells and nuclear aging with dysfunctional telomeres and irreversible cell cycle arrest in stem and cancer cells. Either cytoplasm aging or nuclear aging may cause extracellular senescence‐associated low‐grade inflammation to spread aging. Referring to the recent findings in this special issue of Healthy Aging in CEPP and beyond, we describe the molecular and cellular mechanisms of physiological aging and tissue‐specific pathological aging in chronic diseases.
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Keywords: cytoplasm aging; nuclear aging; organelle degeneration; senescence‐associated low‐grade inflammation; tissue‐specific premature aging

Document Type: Editorial

Publication date: December 1, 2017

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