Skip to main content
padlock icon - secure page this page is secure

Smart bomb AS1411 aptamer‐functionalized/PAMAM dendrimer nanocarriers for targeted drug delivery in the treatment of gastric cancer

Buy Article:

$52.00 + tax (Refund Policy)

Chemotherapy, a conventional method assessed in recent oncology studies, poses numerous problems in the clinical environment. To overcome the problems inherent in chemotherapy, an intelligent drug delivery system has come to the forefront of cancer therapeutics. In this study, we designed a dendrimer‐based pharmaceutical system together with a single‐stranded AS1411 aptamer (APTAS 1411) as a therapeutic strategy. The polyamidoamine (PAMAM)‐polyethylene glycol (PEG) complex was then conjugated with the AS1411 aptamer and confirmed by atomic‐force microscopy (AFM) and Fourier transform infrared spectroscopy (FTIR) .In this study, we show that the conjugated PAMAM‐PEG‐APTAS 1411complex dramatically increased PAMAM‐PEG‐5‐FU uptake by MKN45 gastric cancer cells. We also demonstrated both the stability of the nanoparticle‐5‐FU‐APTAS 1411 complex, by thin layer chromatography (TLC), and an increase in 5‐fluorouracil (5‐FU) accumulation in the vicinity of cancerous tumors. This smart drug delivery system is capable of effectively transferring 5‐FU to MKN45 gastric cancer cells in consistent and without toxic effects.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: 5‐fluorouracil; PAMAM; aptamer; drug delivery; nucleolin

Document Type: Research Article

Publication date: January 1, 2017

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more